Roche xCELLigence System for Cell Analysis to Provide Predictive Mechanistic Information for Small Molecule Compounds

PENZBERG, Germany--(BUSINESS WIRE)--The extent to which protein targets are modulated by drugs or small molecule compounds depends on a number of factors, including the expression levels of the target, the effective concentration of the compound, and the time needed for the compound to perturb the target. One of the limitations of current multidimensional phenotypic profiling approaches is that typically a single time point is chosen to assess the effect of compounds. The conclusion, regarding the compounds´ mechanism of action, is based on the time point at which the samples are processed.
To address these restrictions, researchers Abassi et al. (1) have devised a live cell morphological profiling approach for dynamic monitoring of the effect of small molecule compounds that was based on impedance measurement of cells with the xCELLigence RTCA System of Roche Applied Science (SIX: RO, ROG; OTCQX: RHHBY). The approach was tested by screening a library containing FDA approved drugs, experimental compounds, and natural compounds. Compounds with similar activity produced similar impedance-based Time-dependent Cell Response Profiles (TCRPs). The compounds were clustered then based on TCRP similarity.
The researchers identified novel mechanisms for existing drugs, confirmed previously reported calcium modulating activity for COX-2 inhibitor celecoxib, and discovered an additional mechanism for the experimental compound monastrol. They also recognized and characterized a new antimitotic agent. This approach will also help to detect the off target effect of a given compound.
The TCRP technique described by Abassi et al. can overcome the limitations of current approaches, because the profile generated is time dependent. In combination with measurement of cell number, morphology, and adhesion, the TCR technique allows greater expansion of the ‘‘biological space’’ at which compounds are screened. It provides ample opportunity to detect and identify biological activity associated with small molecules.
In conclusion, these findings indicate that the time-dependant resolution, provided by the TCRP approach, can be used in conjunction with phenotypic profiling approaches to obtain additional data associated with small molecule compounds. TCRP approach provides predictive mechanistic information for small molecule compounds.
The non-invasive and label-free xCELLigence analysis method, originally invented by ACEA Biosciences in San Diego, USA is based on measuring the impedance of cells. The technique utilizes an electronic readout of impedance to non-invasively quantify cellular status in real-time. Cells are seeded in E-Plate microtiter plates, which are integrated with microelectronic sensor arrays. The interaction of cells with the microelectrode surface generates a cell-electrode impedance response, which not only indicates cell viability but also correlates with the number of the cells seeded in the well. In conjunction with its user-friendly data collection and analysis capabilities, the xCELLigence System makes a unique platform for continuous, real-time cell-based assays and provides a huge opportunity for cellular and molecular biology.
For more information on the technology, please visit www.roche-applied-science.com.
courtesy: google alerts

[bioinfo] Theoretical Systems Biology Postdoc]

Postdoctoral Position in Theoretical Systems Biology, Imperial College London.Applications are invited for a forty-month postdoctoral researchposition (to start anytime beginning from October 2009) on a largeinterdisciplinary research project Mapping Combinatorial StressResponses in Bacteria Using Chimeric Proteins and ProbabilisticModelling. The project will involve the development of mathematicaldescriptions for stress response systems in Escherichia coli andMycobacterium bovis from quantitative transcriptomic, proteomic andmetabolomic data collected as part of a major £3Million BBSRC-fundedinitiative lead jointly by Professor Martin Buck, FRS, and ProfessorMichael Stumpf. The project will employ a total of 10 researchers atImperial College, including seven postdoctoral research associates.This project will deliver quantitative transcriptomic, proteomic andmetabolomic data at high temporal resolution and for a broad range ofbiological stress conditions. The main responsibilities of themodelling post associated with the Theoretical Systems Biology groupwill be the development and application of Bayesian methods for thereverse engineering of the stress response dynamics, and analysis ofcross-talk between different pathways. The willingness to engage fullywith the experimental side and the other researchers on this projectis essential, and there is ample scope to become familiar withstate-of-the-art experimental approaches in systems biology.Successful applicants will have a (PhD or equivalent) background andexperience in computational biology, theoretical systems biology,statistics, applied mathematics, biophysics or similar field. Beingable to work effectively in large interdisciplinary team, familiaritywith computational (e.g. C, C++, Java, Python and R) and statisticaltechniques and a good publication track-record are essential. We alsooffer flexible working conditions, excellent career developmentopportunities and very competitive salary.You will be joining a dynamic, international, multidisciplinaryresearch group located within the South Kensington campus. For initialenquiries, please contact Professor. Michael Stumpf(m.stumpf@imperial.ac.uk, +44 (0) 20 7594 5114,www.imperial.ac.uk/theoreticalsystemsbiology)--Magali Michaut, PhDhttp://baderlab.org/MagaliMichaut

iphone can handle you genome now !!!

here is a crazy news that has been released. all the apple mac loversin this forum will like this news or you would have known it! nowiphone is ready to synchronize with illumina biotech company in US tomake iphone carry the genetic information of the phone owners - so asto track the employees and also carry their genomic info!!http://www.apple.com/iphone/business/profiles/illumina/?sr=hotnews.rss[http://www.apple.com/iphone/business/profiles/illumina/?sr=hotnews.rssplease read the article for further details,

Postdoctoral position in cell division and cancer biology, Denmark

A postdoc position is open in the newly started Nilsson Group at BRIC,University of Copenhagen. Research in the group focuses onunderstanding how the spindle assembly checkpoint controls progressionthrough mitosis and how this is deregulated in cancer cells.The project aims at elucidating the role of the essential cell cycleregulator Cdc20 in promoting aneuploidy and chromosome instability incancer cells. A range of techniques including culturing of cancer celllines and time-lapse microscopy will be employed in the project.Strong candidates with a PhD in Life Sciences are encouraged to apply.The successful candidate should have strong experience in molecularand cellular biology. Previous experience in culturing differentmammalian cell lines will be an advantage. Excellent technical skillsand the capacity for productive self-directed research is aprerequisite.BRIC is located close to the center of Copenhagen and has excellentresearch facilities in modern laboratories and offers outstandingworking conditions in a young, dynamic and international researchenvironment. More information about BRIC and the research of NilssonGroup on www.bric.ku.dkThe appointment is for 2 years and scheduled to start January, 2010.Salary, supplement, pension and terms of employment are set byagreement between the Ministry of Finance and The Danish Confederationof Professional Associations on Academics in the State. Currently, themonthly postdoc salary begins around 4.150 Euro incl. supplement pluspension of ca. 700 Euro. Depending on qualifications, a higher salarymay be negotiated. Non-Danish and Danish applicants may be eligiblefor tax reductions, if they have not lived in Denmark the last 3years.Please contact Jakob Nilsson for further information, jakob.nilsson@bric.ku.dkApplicants should submit 3 printed copies of the applicationcontaining curriculum vitae, publication list and copies of degreecertificates. The applications should to be sent to Jakob Nilsson,BRIC, University of Copenhagen, 2200 Copenhagen N, Denmark. Pleasemark the envelopes “Postdoc Nilsson”. Furthermore, the applicantsshould arrange for two letters of recommendation send directly toJakob Nilsson.Application deadline: October 9, 2009at 12.00am. Only printed applications sent by ordinary post andreceived no later than the deadline are taken into consideration.BRIC and University of Copenhagen wish to reflect the diversity ofsociety and welcome applications from all qualified candidatesregardless of personal background.courtesy: www.scholarship-positions.com

[bioinfo] PhD position in evolutionary genomics, Lausanne, Switzerland]

PHD IN FUNCTIONAL EVOLUTIONARY GENOMICSCenter for Integrative Genomics, University of Lausanne, SwitzerlandA PhD student position (~4 years) is available in the evolutionarygenomics group of Henrik Kaessmann in the framework of major newprojects funded by the European Research Council.We are seeking talented and highly motivated applicants (preferably withsome experience/background in molecular evolution), who have strongprogramming skills (or the willingness and drive to acquire them) and aninterest in evolutionary genome analyses using bioinformaticsapproaches. A MSc degree or equivalent is required.Our group has been interested in a range of topics related to thefunctional evolution of genomes from primates (e.g., emergence of newgenes and their functions) and other mammals (e.g., the origin andevolution of mammalian sex chromosomes). In the framework of a new majorline of projects funded by the European Research Council, a large amountof qualitative and quantitative transcriptome data will be produced fora unique collection of tissues from representative mammals by the wetlab unit of the group using next generation sequencing technologies(RNA-Seq). The PhD student will perform integratedevolutionary/bioinformatics analyses based on these data and availablemammalian genomes. The specific project will be developed together withthe candidate.The language of the institute is English, and its members form aninternational group that is rapidly expanding. The institute is locatedin Lausanne, a beautiful city at Lake Geneva.For more information on the group and our institute more generally,please refer to our website: http://www.unil.ch/cig/page7858_en.html
Please submit a CV, statement of research interest, and names of threereferences to: Henrik Kaessmann (Henrik.Kaessmann@unil.ch).--Henrik Kaessmann, Ph.D.Associate ProfessorCenter for Integrative GenomicsUniversity of Lausanne, SwitzerlandE-mail: Henrik.Kaessmann@unil.chPhone: +41 (0)21 692 3960Some recent publications from the lab:Henrichsen, C., Vinckenbosch, N., Zöllner, S., Chaignat, E., Pradervand,S., Frédéric Schütz, Ruedi, M., *Kaessmann, H. and *Reymond, A. (2009)Segmental copy number variation shapes tissue transcriptomes. NatureGenet. 41: 429-9.Potrzebowski, L., Vinckenbosch, N., Marques, A. C., Chalmel, F., Jegou,B. & Kaessmann, H. (2008) Chromosomal Gene Movements Reflect the RecentOrigin and Biology of Therian Sex Chromosomes. PLoS Biol. 6: e80.Brawand, D., Wahli, W. & Kaessmann, H. (2008) Loss of egg yolk genes inmammals and the origin of lactation and placentation. PLoS Biol. 6: e63.Rosso, L., Marques, A. C., Weier, M., Lambert, N., Lambot, M.-A.,Vanderhaeghen, P. & Kaessmann, H. (2008) Birth and Rapid SubcellularAdaptation of a Hominoid-Specific CDC14 Protein. PLoS Biol. 6: e140.Vinckenbosch, N., Dupanloup, I. & Kaessmann, H. (2006) Evolutionary fateof retroposed gene copies in the human genome. Proc. Natl. Acad. Sci. U.S. A. 103: 3220-3225.Marques, A., Dupanloup, I., Vinckenbosch, N., Reymond, A. & Kaessmann,H. (2005) Emergence of young human genes after a burst of retropositionin primates. PLoS Biol. 3: e357.Burki, F. & Kaessmann, H. (2004) Birth and adaptive evolution of ahominoid gene supporting high neurotransmitter flux. Nature Genet. 10:
1061-1063.--Magali Michaut, PhDhttp://baderlab.org/MagaliMichaut

Workshop On Bioinformatics in Genomics and Proteomics October 09 - 10, 2009 IIT Kgp

http://www.iitkgp.ac.in/downloads/BTworkshop.pdfAbout the workshop
The training is primarily targeted towards Teachers and/ or Scientists and a limited number of final year M.Sc. /Ph.D / B.Tech students to acquaint them with the frontier areas of following topics.
Biological data base
Sequence analysis
Molecular modeling
Genomics
Proteomics
Venue: Department of Biotechnology and Computer & Informatics CentreRegistration fees: Rs.1200/-. Accommodation: Limited
How to apply:Send your application in prescribed proforma along with registration fees(payable by demand draft to CEP, STC, IIT drawn on any bank at Kharagpur) on or before by 15th September, 2008.Coordinators: Professor S. C.Kundu / Professor S. Dey / Dr. R P BahadurDepartment of BiotechnologyIIT, Kharagpur 721 302

HANDS-ON TRAINING PROGRAM IN BIOINFORMATICS - IIAR

NOVEMBER 25-27, 2009
Bioinformatics Department of Indian Institute of Advanced Research (IIAR) is holding a hands-on-training program on various bioinformatics techniques from November 25-27, 2009 for post-graduate students, faculty members and Industry representatives. The training shall cover major topics like homology search, modeling, docking, phylogeny, comparative genomics. Participants will also be allowed to solve live problems. Few lectures will be delivered by eminent faculties. The fees for the program is Rs. 3000/- per head which cover lunch, tea, etc. Participants will have to make their own arrangements for stay. Application form and program detail can be download from Program details and Application form. For further information send email at bioinfo.training@iiar.res.in or call at 079-30514150/154
Coordinator:Dr. Desh Deepak SinghIIAR, Koba Institutional Area,Gandhinagar, 382007

Job opening at Univ. of Minnesota

RESPONSIBILITIES: The successful candidate will work closely with researchers and other Bioinformatics consultants within the Masonic Cancer Center to provide computational support for projects. Emphasis will be placed on current Cancer Center researchers’ priorities, such as the development of forward genetic gene discovery pipelines, software for gene expression analysis, and global identification studies of transcription factor binding sites or altered methylation states. In cooperation with IT professionals at the Minnesota Supercomputing Institute, the Bioinformatics consultants within the Masonic Cancer Center will work towards creating modular and reusable web-accessible tools for researchers to process, explore, and analyze their data sets. Duties: - Consult with Masonic Cancer Center researchers to match leading Bioinformatics technologies to their research programs. - Plan and carry out computational analyses. - Participate in the design, implementation, and maintenance of analysis pipelines for biological research data. - Develop prototype versions of software tools to analyze the data from emerging biotechnologies. - Assist in the evaluation of third-party software tools. - Work collaboratively with Masonic Cancer Center researchers, other members of the Cancer Center Bioinformatics group, and other informatics groups on campus. - Assist in the writing and preparation of grant proposals. REQUIREMENTS: Bachelors degree in computer science, molecular biology, or other scientific discipline, with three years additional on-the-job training in Bioinformatics. Applicants must have experience working with team members with both biological and computational backgrounds. Candidates must have a general understanding of molecular biology and basic genetics concepts. Additionally, candidates should have a minimum of three years of computer programming experience. Strong communication skills and rigorous documentation habits are required. PREFERENCES: An advanced degree, such as a Masters or Ph.D., in the computational sciences is preferred. Experience in the development of server-side Web applications, especially database-backed systems, is highly desirable. Experience with Perl, Java, JavaScript, and SQL is also highly desired. Experience with web application development frameworks such as Ruby on rails and with Ajax support tools (e.g., Prototype, jQuery, Google’s GWT) is preferred. HOW TO APPLY: To apply, go to: http://employment.umn.edu/applicants/Central?quickFind=81228

Job opening at Univ. of Minnesota

RESPONSIBILITIES: The successful candidate will work closely with researchers and other Bioinformatics consultants within the Masonic Cancer Center to provide computational support for projects. Emphasis will be placed on current Cancer Center researchers’ priorities, such as the development of forward genetic gene discovery pipelines, software for gene expression analysis, and global identification studies of transcription factor binding sites or altered methylation states. In cooperation with IT professionals at the Minnesota Supercomputing Institute, the Bioinformatics consultants within the Masonic Cancer Center will work towards creating modular and reusable web-accessible tools for researchers to process, explore, and analyze their data sets. Duties: - Consult with Masonic Cancer Center researchers to match leading Bioinformatics technologies to their research programs. - Plan and carry out computational analyses. - Participate in the design, implementation, and maintenance of analysis pipelines for biological research data. - Develop prototype versions of software tools to analyze the data from emerging biotechnologies. - Assist in the evaluation of third-party software tools. - Work collaboratively with Masonic Cancer Center researchers, other members of the Cancer Center Bioinformatics group, and other informatics groups on campus. - Assist in the writing and preparation of grant proposals. REQUIREMENTS: Bachelors degree in computer science, molecular biology, or other scientific discipline, with three years additional on-the-job training in Bioinformatics. Applicants must have experience working with team members with both biological and computational backgrounds. Candidates must have a general understanding of molecular biology and basic genetics concepts. Additionally, candidates should have a minimum of three years of computer programming experience. Strong communication skills and rigorous documentation habits are required. PREFERENCES: An advanced degree, such as a Masters or Ph.D., in the computational sciences is preferred. Experience in the development of server-side Web applications, especially database-backed systems, is highly desirable. Experience with Perl, Java, JavaScript, and SQL is also highly desired. Experience with web application development frameworks such as Ruby on rails and with Ajax support tools (e.g., Prototype, jQuery, Google’s GWT) is preferred. HOW TO APPLY: To apply, go to: http://employment.umn.edu/applicants/Central?quickFind=81228

Another job opening at INCa-Synergie Bioinformatics Facility for Cancer Genomics, Lyon, France

Wanted: Experienced bioinformatician specialized in biological databases 1.1- Background Recognizing the new opportunities offered by next generation sequencing technologies in the field of cancer genomics, the French National Cancer Institute (INCa) has pledged to provide a major contribution to the International Cancer Genome Consortium (ICGC- http://www.icgc.org/) through the study of two cancer types (hepatocellular carcinoma and HER2 amplified breast tumors). In the near future, INCa is considering contributing more tumor types. The entire sequencing of multiple pairs of tumor and matched germline DNAs has already been completed in France and other pairs are rapidly following. In order to overcome the challenges raised by the massive amount of sequence data that has been and will be generated by such programs, INCa and the Lyon community through the Synergie Lyon Cancer Foundation (http://www.synergielyoncancer.com/) are joining efforts to create a dedicated bioinformatics facility. The objective of the bioinformatics facility will be to empower the biomedical teams working in the field of cancer to best exploit the data generated through large scale genomic projects, notably those funded by INCa and in the first place those taking place within the ICGC. 1.2 Context The INCa-Synergie facility is located in a major French comprehensive cancer center (Centre Leon Berard) with a very active research department (http://oncora1.lyon.fnclcc.fr/english_version/index_eng.html). It is in close proximity to the International Agency for Research on Cancer, IARC. The facility is integrated into the "Pole Rhone-Alpes de Bioinformatique, PRABI (http://www.prabi.fr/), which federates major bioinformatic teams. Thus the facility benefits both from strong biomedical and bioinformatics environments. It is acquiring a large HPC equipment. The facility will open over the coming months four positions for experienced bioinformaticians who will work under the supervision of the facility director, Pr. Gilles Thomas. This job description corresponds to one of these positions. 1.3 Description of duties Working in a team of experienced bioinformaticians and in close collaboration with French partner groups and international research centers, the candidate will : be in charge of the design, development, implementation and maintenance of a high performance storage database enabling the integration of very large volumes of heterogeneous genomic data using different technologies (row storage, column storage, xml, key-value …) while respecting accepted standards. This database, interconnected and in communication with the major genomic databases of the scientific community, will be the core of a platform dedicated to data mining for both local and distant research teams. In addition, the database will offer interfaces (API) which will permit the development of innovative analytic tools. be a major player in providing the organization and implementing the procedures to develop the facility in accordance with the ISO 9001:2000 standard. develop tools such as ETL (Extract-Transform-Load) in order to import or export data in an automatic or semi-automatic manner. continually evaluate, in the context of the platform, new technologies which may be of interest in the scientific field. bring her/his expertise in managing data to specific requests from the collaborating research teams. 2- REQUIRED QUALIFICATION 2.1 Education: Advanced university degree (Masters, PhD) in bioinformatics. 2.2 Skills design and development of databases for the management and analysis of large heterogeneous data sets. modeling schemes for databases (relational databases, entity-association models, UML, …) and associated programs. implementation and optimization of relational database management systems (Oracle, Postgres, MySql, …). knowledge of the major genomic databases and their interfaces. knowledge of querying languages such as SQL. major script, programming and markup languages (shell, awk, perl, python, php, ruby, ajax, javascript, java, c, c++, XML). 2.3 Professional experience At least two years of relevant professional experience at the international level in the field of bioinformatics and/or data base management is required. Prior experience in quality assurance procedures will be highly appreciated. 2.4 Complementary information: Communication in French is not required but advanced English language, excellent communication and interpersonal skills are essential. The candidate should be self motivated, capable of working both independently and within a closely interacting team of scientists and be able to deliver a quality product with fixed deadlines. 3- CONTRACT AND SUBMISSION PROCEDURE 3.1 Contract : Fixed term appointment (two years, renewable once) will be offered to the successful candidate. At the end of a 4 year period and depending on circumstances, a long term position may be considered. Starting date will depend on availability of the successful candidate. It may be as early as October 2009. 3.2 Work location : Lyon, France 3.3 Submission procedure : Letter of motivation, curriculum vitae and addresses of three referees are to be provided in electronic form to the following e-mail address : synergie_vacancies@prabi.fr , prior to September 15, 2009. Acknowledgement of receipt will be forwarded to each candidate. Selected candidates will be invited to come to Lyon, France for an interview. Prior to the closing date, general enquiries about the open position may be sent to the same e-mail address.

Microbiology/Molecular Biology JRF Openings @ School of Biotechnology & Genetic Engineering, BHARATHIAR UNIVERSITY

applications are invited for jrf position in the following university.

Department of BiotechnologySchool of Biotechnology & Genetic EngineeringBHARATHIAR UNIVERSITYCoimbatore – 641046, Tamilnadu
JRF - 2 Posts
Project Title : 1. Novel ARS operon homologues from arsenic resistant indigenous bacterial strain Bacillus indicus (Funded by DBT, New Delhi)
2. Bacterial biodiversity of Western Ghats in search of novel species (Funded by DST, New Delhi)
Fellowship : 12,000 + HRA p.m for 1st & 2nd yr; 14,000 + HRA p.m 3rd for yr
Eligibility MSc Biotechnology / Microbiology / Biochemistry / Life sciences with good academic record. (Age limit- Below 40 Years)
Preference Candidates who have cleared CSIR-UGC-JRF or NET /Equivalent qualified or a Valid GATE score.
Walk In Interview August 28, 2009

courtesy: help biotech

Post-Doctoral Position @Environmental Bioinformatics and Computational Toxicology Center

Post-Doctoral position available at the Environmental Bioinformatics and Computational Toxicology Center (ebCTC).ebCTC is a research consortium of the University of Medicine and Dentistry of NJ - Robert Wood Johnson Medical School, Princeton University, Rutgers University, and USFDA's Center for Toxicoinformatics. (For more information see http://ebctc.org.)The candidate will work directly with ebCTC investigators in problems of multiscale computational biology involving molecular, cellular, and physiological systems. Research tasks include the development and evaluation of process modeling and bioinformatics methods for applications to toxicological and environmental health risk analysis .Experience with software tools such as Matlab, R, BioConductor, ArrayTrack, Ingenuity Pathway Analysis, etc. is useful. Experience in the molecular modeling of ligand-receptor interactions; the analysis of regulatory and developmental bionetworks; the pathway interpretation of genomic, proteomic and metabolomic data; physiologically-based pharmacokinetic and pharmacodynamic modeling; and in related areas will be considered a plus.This Post-Doctoral Fellowship is for two years and carries an annual stipend of $42-46 K depending on experience and qualifications. Location - UMDNJ, Piscataway, NJ.Please send your CV and an introduction letter to Prof. Panos Georgopoulos - panosg@ccl.rutgers.edu and CC to Linda Everett - lindaeve@ccl.rutgers.edu.

Courtesy
Bioplanetjobs.com

Bioinformatics Postdoctoral Research Scientist at Center for Comprehensive Informatics, Emory University

The Emory University Center for Comprehensive Informatics is seeking applications for a Postdoctoral Research Scientist position in Bioinformatics.

Qualifications
The candidate should have a PhD or MD/PhD degree with strong genetics or molecular biology as well as computer science or bioinformatics background.

The position will perform integrative data analysis of multiple types of high-throughput genomic and expression data and develop necessary associated software tools. Projects will focus on development of tools for integration of microarray, microRNA, genetic copy number, CpG methylation, genome sequence, histopathology, and patient outcome data. Opportunities for integration of additional public datasets will also be available.The Emory Center for Comprehensive Informatics implements a broad research and development agenda in biomedical informatics, translational research informatics, grid computing, high performance computing and imaging informatics. The Center develops open source, innovative software systems, tools and applications through synthesis of advanced computer science in high performance and grid computing, biomedical informatics and translational research informatics. Over the next few years, the Center’s principal biomedical informatics research objective will be to develop principles, techniques and tools that can be used by biomedical researchers to assemble a coherent biomedical picture by integrating information from multiple complementary data sources. Its approach is to develop analysis techniques and knowledge management systems so that investigators can explore different ways of synthesizing information from multiple disparate data sources, allowing researchers to generate and test biologically meaningful hypotheses. Interested candidates should send cover letter, Curriculum Vitae, and references to: careers.cci@emory.edu


For further information about The Emory University Center for Comprehensive Informatics plz follow the link:

http://cci.emory.edu

Courtesy
Bioplanetjobs.com

Vacany at CDFD Hyderabad

Applications are invited for the post of scientist at the cdfd Hyderabad.

Essential Qualification:

Phd in any branch of life sciences.
Minimum 3 years of research experience.

Desirable:
Knowledge of various bioinformatics software,matlab etc

Last date to apply:
21st sep 2009

For further information plz follow the link:

http://www.cdfd.org.in/Rcrtmnts/adv1_2009.pdf

Courtesy
Helpbiotech

[bioinfo] 15 months position in bioinformatics in France]

15 months Bioinformatician positionThe laboratory "Mathématique, Informatique et Génome " (MIG) from theFrenchNational Institute of Agriculture Research located at Jouy-en-Josas,nearParis is looking for a highly motivated engineer or post-doc inbioinformatics to work on the Meetac project.Project Abstract :Beyond its fundamental interest, understanding the implantationprocess is ofmajor importance in livestock species since the peri-implantationconceptusloss account for more than 35% of the pregnancy failure. Consequently,whenpregnancy does not establish properly, repeated services (artificialinseminations or embryo transfer) are required, with a negative impactoncalving intervals and a significant economical loss for livestockproducers.Implantation failures are diagnosed with a few biological markers(such asprogesterone and pregnancy-associated proteins) that discriminate thepregnancies failures rather late. An earlier and reliable diagnosismethod forsuch pregnancy loss is therefore a necessity and a challenge for thedairyindustry and would be promoted by the in depth investigation of thematernal-conceptus dialogue. In the last decade, high throughputtranscriptomic analyses have provided major advances in theunderstanding ofthe uterine physiology (mouse, human, livestock) and of the embryodevelopment(mouse, livestock), under physiological or pathological conditions.Integrating data from both uterine and conceptus compartmentssimultaneouslyis of major importance since the establishment and the success of thisdialogue require these two parts. This project will thus deal withbovinereproductive physiology, aiming at a comprehensive and integrativeinterpretation of the gene expression profiles generated on bothextra-embryonic and uterine tissues during the implantation period incattle.As in other mammalian species, such analyses (gene expression profiling,protein expression and interactions) have not been reported yet sothat thisproject looks like a real challenge to move along from genes to farmingreality. A back and forth analysis will thus be required, fromtranscriptabundances to gene networks, from genes to predictive biochemicalinterfaces,from in silico predictions to biological validations in experimentalconditions (vitro, vivo) and ultimately from these physiologicalconditions tofarming realities of early pregnancy loss. This last point will thencritically evaluate our scientific goals in the view of a “bench tolitterside” integrative approach.The candidate will participate to the missions assigned to MIG in thisproject:* Functional annotation of the the genes composing the bovine arrays* Identification of the putative bovine promoters and analysis of the TFbinding site* Integration of all the predictions into a single database.To achieve this missions, the candidate will have to extend existingsoftware(devellopped externally or in the laboratory).Qualifications and experience :Applicants should have : - at least a master in bioinformatics or amaster incomputer science with a good knowledge in biology; - strongprogramming skills(knowledge of at least one of the following languages : Java, C, C++or Perl);- ability to easily communicate with a variety of scientists(biologists,mathematicians,bioinformaticians) and to work within a team. - A priorexperiment in sequence analysis is an advantagePosition :15 months position in the Jouy en Josas INRA center (15 km SW ofParis) starting 1st of October. Salary depends on professionalexperience.Minimum gross salary is 2200 euros per month.Application :Applications must contain:* a curriculum vitae, - a letter of intent indicating the position youare applying to, and explaining your motivations* the e-mail addresses, phone numbers, and addresses of two scientistsfor reference* your source of information about this job offer.Applications must be sent to Jean-François Gibrat<jean-francois.gibrat@jouy.inra.fr> and Valentin Loux :<valentin.loux@jouy.inra.fr> before September 25th 2009.Further informations :INRA : <http://www.international.inra.fr/>MIG :<http://mig.jouy.inra.fr>Biowic : <http://biowic.inria.fr>Do not hesitate to contact us for complementary information.--Magali Michaut, PhDhttp://baderlab.org/MagaliMichaut

Postdoctoral position: Mathematical modeling of human metabolism : Reykjavik, Iceland

The Center of Systems Biology, University of Iceland (www.systemsbiology.is, CSBUoI) is looking to recruit a highly motivated postdoctoral fellow to join a growing effort focusing on systems biology of human metabolism. The research at the CSB UoI focuses on 1) human metabolism and 2) industrial biotechnology. The Center is an interdisciplinary center with the Schools of Medicine, Engineering and Natural Sciences participating.
The CSB UoI has been awarded an ERC grant to characterize human disease using a systems biology approach. The research effort focuses on 1) expanding the currently available human metabolic reconstruction, 2) discovery of new functions and pathways in human metabolism using computational and experimental techniques, 3) phenotyping of human cell lines using metabolomic techniques, 4) computational and experimental analysis of metabolic changes associated with disease, and 5) high-throughput drug screening. We use the state-of-the-art computational methods to guide and design human cell culturing experiments as well as metabolomic measurements. These technologies are embedded in a biologically driven research program that aims at systematic understanding of human metabolism, disease manifestation and drug target identification.
The successful candidate will be expected to work on expanding the human metabolic reconstruction and lead the computational gap filling effort. The postholder will also mine databases and genomic information, participate in protein annotation of this human metabolism project and will be expected to provide curation and quality control for the protein functional annotation framework. In addition, the postholder will be part of a team to develop quantitative tools required to expand mass spectrometry capabilities and integrative bioinformatics at the CSB UoI.
The ideal candidate will hold a PhD in Bioinformatics or related field and have a strong background in biology as well as computational modelling. All projects at the CSB UoI are interdisciplinary; therefore, a strong motivation to collaborate with experimental groups is required. Programming skills and knowledge of computational methods used in systems biology are required. Knowledge of human metabolism and drug metabolism will be advantage. Individuals with backgrounds in metabolic network reconstruction or metabolic engineering are especially encouraged to apply. Furthermore, the candidate must be fluent in English. Additionally, the candidate must have excellent communication and interpersonal skills and be capable of working within a team of biologists and programmers.
All applications and inquires should be directed to Professor Ines Thiele (systemsbiology@hi.is) by the deadline of September 15th, 2009. All applications will be answered and applicants will be informed about the appointment when a decision has been made. Salary for the positions will be according to collective wage and salary agreement.
Appointments to the University of Iceland do take into account the Equal Rights Project of the University of Iceland.

Postdoctoral Position : Boston, MA

Job Description:
A postdoctoral position is available in the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School. Projects involve evaluation of the role of DNA repair pathways in hematopoietic stem cell function, and in lymphoid and neural malignancies through the characterization of germline and conditional mouse models using novel cellular and genomics based approaches. The lab focus is on understanding how defects in Non-homologous end-joining (NHEJ) in DNA repair impact on immunodeficiency and aging associated pathologies, including immune system decline, stem cell dysfunction and cancer. We are interested in the genomic stability maintenance functions of NHEJ and in this context, the interplay between various repair pathways with DNA damage response (DDR) and cell cycle checkpoints to prevent malignant transformation. We are developing novel stem cell based and state of the genomics based methodologies to examine the mechanisms of tumor initiation and progression in both in vitro and in vivo settings.
The lab uses multidisciplinary approaches that include biochemistry, molecular biology, cell biology, cytogenetics and genetic analysis through the modulation of mouse cancer models, and has developed novel genomics based approaches to survey the genes and epigenetic landscape that underlie disease development. Therefore, the successful candidate must be willing to work with and handle mice, and have knowledge and prior experience with gel electrophoresis, immunoblotting, cloning, PCR, tissue culture and transfection of mammalian cells, work in bacterial cells, have worked with or have the willingness to work and manipulate with mouse embryonic stem cells and routine biochemistry approaches are desirable. Individuals with bioinformatics background with interest in modulation of stem cell technologies are particularly desirable.
We are looking for only self-motivated individuals to become involved in the exciting and challenging environment of the laboratory. The successful candidate will have the opportunity to play a major role in the expansion of the laboratory, and will be exposed to many cutting edge technologies in the cell and molecular biology of cancer, including cytogenetics, noncoding RNA and gene expression analysis, proteomics, bioinformatics and biochemistry. This will be a great opportunity for recent and upcoming PhD and MD, or MD. PhD graduates to address fundamental questions in aging and cancer through the utilization of state of the approaches. The successful applicant must be able to work individually as well as within a group. The duties of the successful candidate will be to develop and conduct research projects in the laboratory in one or more areas through the utilization and modulation of mouse models in both in vitro and in vivo settings. The environment of the lab allows for a great deal of interaction with the principal investigator, other members of the lab and other researchers within the Harvard Medical School campus including the BIDMC Cancer Center, Harvard Stem Cell Institute, IDI andBBS programs. PhD or MD/PhD in Molecular biology/Cell Biology/Biochemistry/Immunology or related field is preferred. Motivated MDs/clinical fellows with interest in lab research may also apply if they have independent lab experience and understanding in the relevant fields. Please send recent CV/biosketch with reference contacts by email to Dr. Catherine Yan atcyan@bidmc.harvard.edu.

Free Supercomputer Access

The Supercomputing Facility at IIT Delhi is committed towards the scientific community in providing state of the art high performance computing environment along with necessary tools to exlore the new frontiers in Bioinformatics and Computational biology. The resources and facilites provided by SCFBio are geared to cater for specific scientific research work in life science area.
You can create an account in our Supercomputer and run your computationaly intensive programs in our Supercomputer.
To get an account on the SCFBio Supercomputer the user has to fill a form abiding with the terms and conditions mentioned therein.
Access Request Form: [ Download ]
Fax or post the complete form to the following address:
Supercomputing Facility for Bioinformatics and Computational Biology,Synergy Building, 3rd Floor , IIT Campus,Hauz Khas, New Delhi -110016Fax -+ 91-011-26582037 For any further query feel free to drop a mail at : biogrid@scfbio-iitd.res.in

Free Supercomputer Access

The Supercomputing Facility at IIT Delhi is committed towards the scientific community in providing state of the art high performance computing environment along with necessary tools to exlore the new frontiers in Bioinformatics and Computational biology. The resources and facilites provided by SCFBio are geared to cater for specific scientific research work in life science area.
You can create an account in our Supercomputer and run your computationaly intensive programs in our Supercomputer.
To get an account on the SCFBio Supercomputer the user has to fill a form abiding with the terms and conditions mentioned therein.
Access Request Form: [ Download ]
Fax or post the complete form to the following address:
Supercomputing Facility for Bioinformatics and Computational Biology,Synergy Building, 3rd Floor , IIT Campus,Hauz Khas, New Delhi -110016Fax -+ 91-011-26582037 For any further query feel free to drop a mail at : biogrid@scfbio-iitd.res.in

Bioinformatics Group CFP: Bioinformatics Track @ ACM SAC 2010 - due Sep 8, 2009

Bioinformatics and Computational Systems Biology TrackThe 25th ACM Symposium on Applied Computing22 - 26 March 2010Sierre, Switzerland http://www.nrcbioinformatics.ca/acmsac2010/Track description and motivationsThe publishing of the draft of the human genome and the recent advancements in high throughput sequencing and functional genomics technologies has ushered in a new era of rapid and exponential growth of data related to how organisms function at the molecular level. A major part of the information to support this understanding is available on large number of heterogeneous databases in both structured and unstructured formats. One challenge is to obtain information and knowledge from these databases and integrate them in a semantically consistent way, in order to be able to analyze them using novel quantitative conceptual and computational approaches smoothly connecting models and experiments. This can offer life scientists a deeper system-level understanding of fundamental biological principles. Examples of computational challenges in this new research paradigm, called systems biology, include identification of biological pathways, structure annotation of proteins, inference of biochemical networks and pathways using experimental data, information, and knowledge scattered over heterogeneous databases. The convergence of computer science and biology is both a data- and model- driven new science that necessitates the development of mathematical/computational models and data mining algorithms, that can enable scientists and bio-engineers to analyze with predictive ability biological information that guide the development of therapeutic and biotechnology solutions. This track is motivated by the rapidly growing importance of the informatics vision for novel levels of understanding in complex biological and biomedical systems, and will address research issues related to the whole spectrum of bioinformatics with a particular focus on integrative, inferential and translational bioinformatics.List of topicsPapers are solicited in, but not limited to the following areas:* Algebraic biology* Bio imaging* Bioinformatics for drug design & discovery* Biological databases, warehousing and management* Biomedical data integration, metadata & ontologies* Biomarker identification and annotation* Biomedical text mining* Computational and Comparative genomics* Data visualization and visual analytics* Disease informatics* Evolution and phylogenetics* Gene expression/regulation & microarrays* Healthcare applications* High-performance bio-computing* Inference of biochemical network models from experimental data* Integrative bioinformatics* Laboratory information management systems in biology* Model driven analysis of biological systems* Modeling, analysis and Inference of gene and protein networks* Molecular modeling and simulation* Molecular sequence analysis* Pathways identification* Population genetics* Proteomics* Protein & RNA structure and function* Protein structure prediction and modeling* Recognition of genes and regulatory elements* Semantic technologies for life sciences* Sequence analysis & alignment* SNPs, mutations and haplotyping* Structural bioinformatics* Tool integration, web services and workflow systemsPapers submissionAll submissions should represent original and previously unpublished works that are currently not under review in any conference or journal. Both basic and applied research papers are welcome. The author(s) name(s) and address(s) must NOT appear in the body of the submitted paper, and self-references should be in the third person. This is to facilitate blind review required by ACM. All submitted papers must include the paper identification number on the front page, above the title of the paper provided to you by the eCMS when you register your paper. All enquiries and questions should be directed to the Track Chairs. Additional details are available at the track home page at http://www.nrcbioinformatics.ca/acmsac2010/ . Important datesPaper submission: September 8, 2009Notification of paper acceptance/rejection: October 19, 2009Camera ready: November 2, 2009Conference Paper Publication All papers will be fully refereed and undergo a blind review process by at least three referees. The conference proceedings will be published by ACM. Hence, all accepted papers should be submitted in ACM 2-column camera-ready format for publication in the symposium proceedings. The final version of the paper should not be more than 5 pages long. An additional 3 pages are allowed with a charge of 80USD per extra page. Final Camera-ready submissions must follow the template available at: http://www.acm.org/conferences/sac/sac2010/.Publication in Journal/BookExpanded versions of selected papers will be published as a special IGI Global book volume. Authors will be contacted after the presentation of these papers at the SAC Conference.Poster Publication of Selected Papers A set of selected papers will be accepted as poster papers by invitation only and will be published as short papers in the symposium proceedings.Track chairsPaola Lecca, Ph.D.Microsoft Research CenterUniversity of Trento, Italy.Email: lecca at cosbi.euKanagasabai Rajaraman, Ph.D.Institute for Infocomm Research, Singapore.E-mail: kanagasa at i2r.a-star.edu.sgDan Tulpan, Ph.D.Institute of Information Technology National Research Council of Canada, CanadaE-mail: dan.tulpan at nrc-cnrc.gc.ca
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Many thanks to Dr. Kanagasabai Rajaraman for forwarding this email..