[bioinfo] Theoretical Systems Biology Postdoc]

Postdoctoral Position in Theoretical Systems Biology, Imperial College London.Applications are invited for a forty-month postdoctoral researchposition (to start anytime beginning from October 2009) on a largeinterdisciplinary research project Mapping Combinatorial StressResponses in Bacteria Using Chimeric Proteins and ProbabilisticModelling. The project will involve the development of mathematicaldescriptions for stress response systems in Escherichia coli andMycobacterium bovis from quantitative transcriptomic, proteomic andmetabolomic data collected as part of a major £3Million BBSRC-fundedinitiative lead jointly by Professor Martin Buck, FRS, and ProfessorMichael Stumpf. The project will employ a total of 10 researchers atImperial College, including seven postdoctoral research associates.This project will deliver quantitative transcriptomic, proteomic andmetabolomic data at high temporal resolution and for a broad range ofbiological stress conditions. The main responsibilities of themodelling post associated with the Theoretical Systems Biology groupwill be the development and application of Bayesian methods for thereverse engineering of the stress response dynamics, and analysis ofcross-talk between different pathways. The willingness to engage fullywith the experimental side and the other researchers on this projectis essential, and there is ample scope to become familiar withstate-of-the-art experimental approaches in systems biology.Successful applicants will have a (PhD or equivalent) background andexperience in computational biology, theoretical systems biology,statistics, applied mathematics, biophysics or similar field. Beingable to work effectively in large interdisciplinary team, familiaritywith computational (e.g. C, C++, Java, Python and R) and statisticaltechniques and a good publication track-record are essential. We alsooffer flexible working conditions, excellent career developmentopportunities and very competitive salary.You will be joining a dynamic, international, multidisciplinaryresearch group located within the South Kensington campus. For initialenquiries, please contact Professor. Michael Stumpf(m.stumpf@imperial.ac.uk, +44 (0) 20 7594 5114,www.imperial.ac.uk/theoreticalsystemsbiology)--Magali Michaut, PhDhttp://baderlab.org/MagaliMichaut