Develop Novel therapy against stroke in Diabetes at Karolinska Institutet, Sweden

Project Title: Developing novel therapies against stroke in diabetes.


Area of responsibilities/description of the work
The project is about developing a new therapy for the treatment of stroke in diabetic patients. The methods involve systemic and stereotaxic intracerebral injections of drugs in rodents, applying novel treatments to rodents with a stroke induced by middle cerebral artery occlusion. Knockout mice are used for certain projects. Analyses include: histology; immuno-histochemistry; behavioral tests; real time quantitative RT-PCR; Western blotting.

The project is multidisciplinary and it will be run within the Unit of Diabetes Research headed by Professor Åke Sjöholm. Our Research Center has excellent core facilities, a highly interactive scientific environment and the goal to translate our research to the clinic.

Project Title: Developing novel therapies against stroke in diabetes.


Area of responsibilities/description of the work
The project is about developing a new therapy for the treatment of stroke in diabetic patients. The methods involve systemic and stereotaxic intracerebral injections of drugs in rodents, applying novel treatments to rodents with a stroke induced by middle cerebral artery occlusion. Knockout mice are used for certain projects. Analyses include: histology; immuno-histochemistry; behavioral tests; real time quantitative RT-PCR; Western blotting.

The project is multidisciplinary and it will be run within the Unit of Diabetes Research headed by Professor Åke Sjöholm. Our Research Center has excellent core facilities, a highly interactive scientific environment and the goal to translate our research to the clinic.

Qualifications
The candidates should have a Ph.D. in neuroscience and preferably two years postdoc experience at academic or company level. Important backgrounds of the candidate include: rodent neurosurgery, experience in confocal microscopy, behavioural analysis, mouse breeding and genotyping. Expertise in brain regeneration and neural stem cell biology is a plus.

The candidate should be adaptable to work within our Research Center as well as with an already established network involving academic groups within Sweden/EU as well as with companies. For this reason, highly developed skills in communication are a must as well as a proven ability to communicate effectively in English.

The position is for two years with possibilities for an extension. A competitive salary and benefits will be based on experience.
Contact persons
Cesare Patrone, Ph.D., cesare.Patrone@ki.se +46704328349
Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Unit for Diabetes Research.


Instructions: Please send your application, marked with reference number 02080/2009-226, to reach us by no later than August 19 2009 to Cesare Patrone, Ph.D., cesare.Patrone@ki.se. The following documents must be submitted with your application, and written in English:
1. A full CV, including date of public defence, title of thesis, previous academic appointments, academic title, current position, academic distinctions and committee work
2. A full publication list
3. A brief outline of your current work (max. one page)

See Karolinska Institutet´s hompepage at http://ki.se/qualificationsportfolio for information about the qualification portfolio.

Please note that one copy of all documents will be kept by the college for a period of two years, in accordance with a directive from the National Archives. Published material submitted for review is excepted from this rule.

Karolinska Institutet aims to promote equal opportunities by encouraging a balanced gender distribution. We therefore particularly invite women to apply for this position. We also value the qualities that ethnic and cultural diversity can contribute to the university.
   
Karolinska Institutet is one of the leading medical universities in Europe. Through research and education, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine.

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